Tetracaine hydrochloride

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Khoom cim npe

Product details

MF: C15H25ClN2O2
PIB: 300.82
CAS: 136-47-0 Nr

1. Tetracaine hydrochloride yog ib qho tshuaj loog hauv zos uas muaj txiaj ntsig zoo uas tuaj yeem thaiv cov paj hlwb ua haujlwm rov qab.Nws yog siv nyob rau hauv infiltration tshuaj loog, paj hlwb thaiv tshuaj loog, epidural tshuaj loog, thiab lwm yam. piv nrog procaine, nws cov nyhuv tshuaj loog hauv zos yog qhov tseem ceeb, thiab tau dav siv nyob rau hauv tsev kho mob.Los ntawm kev kawm txog cov txheej txheem synthesis uas twb muaj lawm, nws pom tau hais tias cov synthesis ntawm intermediate p-butylamino benzoic acid yog cov kauj ruam tseem ceeb ntawm kev sib txuas ntawm tetracaine hydrochloride, uas muaj qhov tsis zoo ntawm cov khoom siv tsis ruaj khov lossis tsis muaj txiaj ntsig.Cov kws tshawb fawb tau txhim kho qhov no.Hauv xyoo 1981, lawv tau npaj los tsim cov p-butylamino benzoic acid los ntawm alkylating p-aminobenzoic acid nrog 1-Bromobutane.Txawm li cas los xij, vim yog qhov tsim nyog ntawm cov khoom lag luam ntawm dibutylation thiab qhov tsis ruaj khov ntawm cov khoom siv raw, txoj hauv kev no tsis haum rau kev tsim khoom lag luam.

2.Tetracaine hydrochloride yog siv rau mucosal nto tshuaj loog, conduction anesthesia, epidural tshuaj loog thiab subarachnoid tshuaj loog;Siv rau ophthalmic nto tshuaj loog, nws tsis constricting cov hlab ntsha, tsis ua puas corneal epithelium, thiab tsis nce intraocular siab.

3 . Cov tshuaj no tuaj yeem txhim kho cov paj hlwb ntawm cisatracurium, thiab cov koob tshuaj tom kawg yuav tsum tau txo qis thaum ua ke.Thaum ua ke nrog adrenaline, nws tuaj yeem txwv cov hlab ntsha, txo cov ntshav khiav, kev nqus tshuaj qeeb, thiab ua kom lub sijhawm ua haujlwm ntev.Tab sis kev sib xyaw ua ke ntawm ob tsis haum rau cov neeg mob uas muaj kab mob plawv, ntshav siab, hyperthyroidism, peripheral vascular kab mob thiab lwm yam.Hyaluronidase tuaj yeem ua kom muaj qhov sib txawv ntawm cov tshuaj no, ua kom qhov pib ntawm cov tshuaj loog, txo qhov o hauv zos, thiab tiv thaiv kev tsim ntawm hematoma.Txawm li cas los xij, hyaluronidase tuaj yeem ua kom nrawm nrawm ntawm qhov nqus ntawm cov tshuaj no, ua rau muaj kev nce ntxiv ntawm cov tshuaj tiv thaiv tshuaj toxicity ntawm cov tshuaj no.Cov tshuaj no yog derivative ntawm p-aminobenzoic acid (PABA).Sulfonamides siv tshuaj tua kab mob los ntawm inhibiting PABA ntawm cov kab mob.Thaum cov tshuaj no ua ke nrog sulfonamides, cov nyhuv antibacterial ntawm tom kawg yuav raug inhibited, yog li ob qho tib si yuav tsum tsis txhob ua ke.Cov tshuaj no yog acidic thiab yuav tsum tsis txhob tov nrog alkaline kua tshuaj;Txawm tias cov tshuaj acidic tuaj yeem cuam tshuam rau qhov sib txawv ntawm cov tshuaj vim muaj pH sib txawv, ua rau txo qis lossis ncua sij hawm pib.Kev npaj iodine tuaj yeem ua rau nag lossis daus ntawm cov tshuaj no, yog li qhov chaw txhaj tshuaj ntawm cov tshuaj no tsis tuaj yeem siv.

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Cov khoom no yog ib tug ntev-acting ester lub zos tshuaj loog.Nws cov yam ntxwv ua haujlwm yog: muaj zog nkag mus rau mucosa, haum rau qhov chaw tshuaj loog, thiab tsis muaj kev phiv xws li vasoconstriction, mydriasis, pob txha raug mob tom qab qhov muag tee.Nws yog feem ntau siv hauv ophthalmology.Cov nyhuv tshuaj loog hauv zos thiab toxicity yog kwv yees li 10 npaug ntau dua li procaine.Tom qab txhaj tshuaj, cov nyhuv tshuaj loog ntawm cov tshuaj chemical zoo nkaus li maj mam (li 10 feeb), thiab cov metabolism kuj qeeb tom qab nqus tau.Lub sijhawm tshuaj loog hauv zos yog mus txog 3ij, h, -j.txog.Nws yog tsuas yog siv rau qhov chaw tshuaj loog ntawm qhov muag, qhov ntswg thiab caj pas mucosa, thiab tsis tshua siv rau kev siv tshuaj loog thiab tshuaj loog epidural.Feem ntau, nws tsis yog siv rau infiltration tshuaj loog vim nws siab toxicity.

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Sau koj cov lus ntawm no thiab xa tuaj rau peb